1st Edition

Nutrigenomics and Nutrigenetics in Functional Foods and Personalized Nutrition

Edited By Lynnette R. Ferguson Copyright 2014
    451 Pages 63 B/W Illustrations
    by CRC Press

    While functional foods have become a reasonably well-established concept, personalized nutrition is still treated with skepticism by many. The recognition that people would have different nutrient requirements, or perceive foods in different ways, raises several concerns—some real, some not so real. Nutrigenomics and Nutrigenetics in Functional Foods and Personalized Nutrition addresses what is needed to bring nutrigenomics, nutrigenetics, and their associated technologies to market in a truly impactful way.

    Edited by Lynnette R. Ferguson, a well-known and internationally respected researcher, the book covers a wide range of issues, from the purely scientific to ethical, consumer-driven, and public health aspects. It takes a close look at gene–diet interactions and explores the ways in which studies on nutrigenomics and nutrigenetics can help modulate disease risk in cardiovascular disease, obesity, diabetes, and inflammatory bowel disease. Topics include regulatory challenges, genetic testing for consumers, data mining, transcriptomic analysis, and the role of science and health professionals in the commercialization of nutrigenomics and nutrigenetics. The book also examines industry–academia partnerships as a nexus between the science and its commercialization by the food industry. These partnerships will be an important determinant of what value the technologies bring, not only to the market but to the wider health and well-being of society.

    Exploring how nutrigenomics and nutrigenetics can help modulate disease risk, this timely book brings together stimulating, well-thought-out perspectives from established and emerging researchers. It provides valuable information on a subject that is becoming increasingly important for nutritionists, dieticians, and clinical professionals, as well as for the food industry and research community.

    Examples of Some Key Gene-Diet Interactions

    Nutrigenetics and Nutrigenomics: Importance for Functional Foods and Personalized Nutrition
    Lynnette R. Ferguson

    Variations in Solute Transporter Genes Affecting Micronutrient Solute Transport and Human Health
    Peter Eck

    Genetic Variants in the Omega-6 and Omega-3 Fatty Acid Metabolic Pathway: Their Role in the Determination of Nutritional Requirements and Chronic Disease Risk
    Artemis P. Simopoulos

    Nutrigenomic Approaches to Unraveling the Physiological Effects of Complex Foods
    Peter J. Gillies and John P. Vanden Heuvel

    Modifying Disease Risk through Nutrigenetics and Nutrigenomics

    Modulating the Risk of Cardiovascular Disease through Nutrigenetics
    Antonio Garcia-Rios, Javier Delgado-Lista, Pablo Perez-Martinez, Francisco Pérez-Jimenez, and Jose Lopez-Miranda

    Modulating the Risk of Obesity and Diabetes through Nutrigenetics
    Helen M. Roche and Catherine Phillips

    Nutrigenetics and Crohn’s Disease
    Lynnette R. Ferguson

    Microbiome and Host Interactions in Inflammatory Bowel Diseases: Relevance for Personalized Nutrition
    Wayne Young, Bianca Knoch, and Nicole C. Roy

    Importance of Cell-Specific Gene Expression Patterns for Understanding Nutrient and Gene Interactions in Inflammatory Bowel Diseases
    Anna E. Russ, Jason S. Peters, Warren C. McNabb, and Nicole C. Roy

    Technologies in Nutrigenetics/Nutrigenomics

    Data Mining and Network Analysis: Potential Importance in Nutrigenomics Research
    Vijayalakshmi Varma and Jim Kaput

    Metabolomics: An Important Tool for Assessing State of Health and Risk of Disease in Nutrigenomics Research
    Hui-Ming Lin and Daryl Rowan

    Epigenetics—What Role Could This Play in Functional Foods and Personalised Nutrition?
    Matthew P.G. Barnett, Shalome A. Bassett, and Emma N. Bermingham

    Foodomics to Study Efficacy of Human Dietary Interventions: Proof of Principle Study
    Stephanie Ellett, Isobel R. Ferguson, Shuotun Zhu, Nishi Karunasinghe, Gareth Marlow, Daniel Hurley, Wen J. Lam, Dug Y. Han, and Lynnette R. Ferguson

    Considerations in Estimating Genotype in Nutrigenetic Studies
    Angharad R. Morgan

    Bringing Nutrigenomics to Industry, Health Professionals, and the Public

    Bringing Nutrigenomics to the Food Industry: Industry–Academia Partnerships as an Important Challenge
    Ralf C. Schlothauer and Joerg Kistler

    Commercialization and Potential of Nutrigenetics and Nutrigenomics
    Virginia Parslow and Lynnette R. Ferguson

    Bringing Nutrigenomics to the Public: Is Direct-to-Consumer Testing the Future of Nutritional Genomics?
    David Castle

    Nutritional Genomics in Practice: Interaction with Health Professionals in Bringing Nutritional Genomics to the Public
    Colleen Fogarty Draper

    Harvesting Normative Potential for Nutrigenomic Research
    Bart Penders and Michiel Korthals

    Public Health Context for Nutrigenomics and Personalized Nutrition
    Elizabeth H. Marchlewicz, Karen E. Peterson, and Gilbert S. Omenn

    Nutrigenomics and Public Health
    Maria Agelli and John A. Milner



    Lynnette R. Ferguson, D.Phil., D.Sc., QSO, FNZIFST, works at the Auckland Cancer Society Research Centre, using mutagenicity testing as a predictor of carcinogenesis. In 2000, she also took on a 50 percent role as head of the Nutrition Department at the University of Auckland. Her research interests include the interplay between genes and diet in the development of chronic disease, with particular focus on inflammatory bowel disease, a cancer-prone condition, and also in prostate cancer. As program leader for the multidisciplinary-multiorganization Nutrigenomics New Zealand, she is working to bring nutrigenomics tools and potential to the New Zealand science scene. She is the author or coauthor of more than 300 peer-reviewed publications, including chapters in books and articles in international journals. She serves as one of the managing editors for Mutation Research: Fundamental and Molecular Mechanisms of Mutation and is on the editorial boards of several other major journals.