Pharmacotherapy of Cachexia: 1st Edition (Hardback) book cover

Pharmacotherapy of Cachexia

1st Edition

Edited by Karl G. Hofbauer, Stefan D. Anker, Akio Inui, Janet R. Nicholson

CRC Press

608 pages | 72 B/W Illus.

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Hardback: 9780849333798
pub: 2005-12-22
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Although a wealth of information can be found scattered throughout periodicals and research papers, tracking down the most effective treatment for a heterogeneous syndrome such as cachexia can be problematic. Edited by experts in the field, with contributions from a multidisciplinary panel, Pharmacotherapy of Cachexia is the first book devoted solely to the treatment of cachexia with a focus on pharmacotherapeutic aspects.

The book discusses the various aspects of the syndrome and compares and contrasts its diverse treatment options. It explores the topic from a theoretical and practical perspective and provides an overview of currently available and future treatment. The first half of the book includes coverage of pathophysiology, associated diseases, and general therapeutic aspects. The subsequent sections devoted to pharmacotherapy cover drugs in clinical use, drugs in research and development, and the final section focuses on potential future advancements.

Numerous internationally recognized specialists have contributed chapters on the various aspects of cachexia to this book. Their critical evaluation of pathophysiological mechanisms, clinical features, and therapeutic options make it a valuable source of information on all aspects of this serious and life-threatening condition. Expert editorial guidance ensures minimal repetition of information and uniform presentation. Addressing the multiple disease processes associated with cachexia in an organized and useful way, the book is a comprehensive reference for the management of this recalcitrant and hard-to-treat syndrome.

Table of Contents


Malnutrition and Cachexia, C.G. Goncalves, A.L.C. Campos, J.C.U. Coelho, S. Suzuki, and M.M. Meguid

Anorexia: Central and Peripheral Mechanisms, S. Perboni, G. Mantovani, A. Inui, and Y. Takimoto

Skeletal Muscle Atrophy and Hypertrophy, D.J. Glass

Skeletal Muscle Apoptosis in Cachexia and Aging, A.J. Dirks and C. Leeuwenburgh

Neurohormonal Factors, A.L. Clark

Cytokines and the Pathophysiology of Skeletal Muscle Atrophy, V.E. Baracos


Diseases Associated with Cachexia: Cancer, R.J.E. Skipworth, M. Dahele, and K.C.H. Fearon

Cachexia Associated with AIDS, K. Berneis and K. Utech

Rheumatoid Cachexia, L.A. Coleman

Chronic Kidney Disease, B. Lindholm, J. Axelsson, O. Heimbürger, A.R. Qureshi, T. Cederholm, and P. Stenvinkel

Cardiac Failure, P.A. Poole-Wilson

Chronic Obstructive Pulmonary Disease, A.M.W.J. Schols

Cachexia in Older Persons, J.E. Morley


Treatment Goals, A.J.S. Coats

Nutritional Treatment of Cachexia, C. Falconnier and U. Keller


Appetite Stimulants, M. John

Cardiac Cachexia - Drugs in Clinical Use, S. Strassburg and S.D. Anker

ß2-Adrenergic Agonists in the Treatment of Muscle Atrophy, C.P. Lambert, E.Y. Uc, and W.J. Evans

Androgens, Anabolic Steroids, and Glucocorticoids, L. Harle, S. Basaria, and A.S. Dobs

Growth Hormone, P.V. Carroll

Anti-Inflammatory Agents in Cancer Cachexia, M.P. Davis


The Yin and Yang of IGF-1 and Ghrelin, R.G. Clark

Erythropoietin -A Novel Therapeutic Option for Cachectic Patients, P. Ponikowski, E.A. Jankowska, and W. Banasiak

Statins, S. von Haehling and S.D. Anker

Xanthine Oxidase Inhibitors and Insulin Sensitizers, W. Doehner

Tumor Necrosis Factor Inhibitors in the Management of Cancer-Associated Weight Loss Syndrome, S. Patiyil and A. Jatoi


Central Pharmacological Targets, D.L. Marks

The Ubiquitin-Proteasome Pathway, M. Brink

Peripheral Signaling Pathways Involved in Muscle Loss, S. Possekel, T. Meier, and M.A. Ruegg

Perspectives and Outlook, K.G. Hofbauer, S.D. Anker, A. Inui, and J.R. Nicholson

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Nutrition
MEDICAL / Oncology
MEDICAL / Pharmacology