606 Pages 72 B/W Illustrations
    by CRC Press

    Although a wealth of information can be found scattered throughout periodicals and research papers, tracking down the most effective treatment for a heterogeneous syndrome such as cachexia can be problematic. Edited by experts in the field, with contributions from a multidisciplinary panel, Pharmacotherapy of Cachexia is the first book devoted solely to the treatment of cachexia with a focus on pharmacotherapeutic aspects.

    The book discusses the various aspects of the syndrome and compares and contrasts its diverse treatment options. It explores the topic from a theoretical and practical perspective and provides an overview of currently available and future treatment. The first half of the book includes coverage of pathophysiology, associated diseases, and general therapeutic aspects. The subsequent sections devoted to pharmacotherapy cover drugs in clinical use, drugs in research and development, and the final section focuses on potential future advancements.

    Numerous internationally recognized specialists have contributed chapters on the various aspects of cachexia to this book. Their critical evaluation of pathophysiological mechanisms, clinical features, and therapeutic options make it a valuable source of information on all aspects of this serious and life-threatening condition. Expert editorial guidance ensures minimal repetition of information and uniform presentation. Addressing the multiple disease processes associated with cachexia in an organized and useful way, the book is a comprehensive reference for the management of this recalcitrant and hard-to-treat syndrome.

    Malnutrition and Cachexia, C.G. Goncalves, A.L.C. Campos, J.C.U. Coelho, S. Suzuki, and M.M. Meguid
    Anorexia: Central and Peripheral Mechanisms, S. Perboni, G. Mantovani, A. Inui, and Y. Takimoto
    Skeletal Muscle Atrophy and Hypertrophy, D.J. Glass
    Skeletal Muscle Apoptosis in Cachexia and Aging, A.J. Dirks and C. Leeuwenburgh
    Neurohormonal Factors, A.L. Clark
    Cytokines and the Pathophysiology of Skeletal Muscle Atrophy, V.E. Baracos

    Diseases Associated with Cachexia: Cancer, R.J.E. Skipworth, M. Dahele, and K.C.H. Fearon
    Cachexia Associated with AIDS, K. Berneis and K. Utech
    Rheumatoid Cachexia, L.A. Coleman
    Chronic Kidney Disease, B. Lindholm, J. Axelsson, O. Heimbürger, A.R. Qureshi, T. Cederholm, and P. Stenvinkel
    Cardiac Failure, P.A. Poole-Wilson
    Chronic Obstructive Pulmonary Disease, A.M.W.J. Schols
    Cachexia in Older Persons, J.E. Morley

    Treatment Goals, A.J.S. Coats
    Nutritional Treatment of Cachexia, C. Falconnier and U. Keller

    Appetite Stimulants, M. John
    Cardiac Cachexia - Drugs in Clinical Use, S. Strassburg and S.D. Anker
    ß2-Adrenergic Agonists in the Treatment of Muscle Atrophy, C.P. Lambert, E.Y. Uc, and W.J. Evans
    Androgens, Anabolic Steroids, and Glucocorticoids, L. Harle, S. Basaria, and A.S. Dobs
    Growth Hormone, P.V. Carroll
    Anti-Inflammatory Agents in Cancer Cachexia, M.P. Davis

    The Yin and Yang of IGF-1 and Ghrelin, R.G. Clark
    Erythropoietin -A Novel Therapeutic Option for Cachectic Patients, P. Ponikowski, E.A. Jankowska, and W. Banasiak
    Statins, S. von Haehling and S.D. Anker
    Xanthine Oxidase Inhibitors and Insulin Sensitizers, W. Doehner
    Tumor Necrosis Factor Inhibitors in the Management of Cancer-Associated Weight Loss Syndrome, S. Patiyil and A. Jatoi

    Central Pharmacological Targets, D.L. Marks
    The Ubiquitin-Proteasome Pathway, M. Brink
    Peripheral Signaling Pathways Involved in Muscle Loss, S. Possekel, T. Meier, and M.A. Ruegg
    Perspectives and Outlook, K.G. Hofbauer, S.D. Anker, A. Inui, and J.R. Nicholson


    Karl G. Hofbauer, Stefan D. Anker, Akio Inui, Janet R. Nicholson