Principles of Biostatistics

1. Introduction

Part I Variability

2. Descriptive Statistics

3. Rates and Standardization

4. Life Tables

Part II Probability

5. Probability

6. Screening and Diagnostic Tests

7. Theoretical Probability Distributions

8. Sampling Distribution of the Mean

Part III Inference

9. Confidence Intervals

10. Hypothesis Testing

11. Comparison of Two Means

12. Analysis of Variance

13. Nonparametric Methods

14. Inference on Proportions

15. Contingency Tables

16. Correlation

17. Simple Linear Regression

18. Multiple Linear Regression

19. Logistic Regression

20. Survival Analysis

21. Sampling Theory

22. Study Design

Bibliography

Glossary

Statistical Tables

Index

Biography

Marcello Pagano is Professor of Statistical Computing in the Department of Biostatistics at the Harvard School of Public Health. His research in biostatistics is on computer intensive inference and surveillance methods that involve screening methodologies, with their associated laboratory tests, and in obtaining more accurate testing results that use existing technologies.

Kimberlee Gauvreau is Associate Professor in the Department of Biostatistics and Associate Professor of Pediatrics at Harvard Medical School. Dr. Gauvreau’s research focuses on biostatistical issues arising in the field of pediatric cardiology. She also works on the development and validation of methods of adjustment for case mix complexity.

Heather Mattie is Lecturer on Biostatistics and the Co-Director Health Data Science Program at the Harvard School of Public Health.

"Overall, this remains the best resource out there for teaching introductory biostatistics to graduate students in public health and medicine."
-Amy Herring, Duke University

"All in all, this is an excellent manuscript and I commend the authors for writing a compelling text that not only provides a sound, comprehensive introduction to biostatistical methods, but also motivates and illustrates them using engaging and relevant contemporary examples. I eagerly look forward to the forthcoming publication of the third edition."
-Yue Jiang, Duke University

"This book is a useful reference on standard biostatistics topics suited for those with limited mathematical and statistical experience and can certainly be used (and has) as text for persons in programs in the health sciences."
-Peter Wludyka in Technometrics, April 2023

"The new edition is indeed a pleasant surprise. First, the presentation differs from the previous two editions by dividing the book into three parts—variability, probability, and inference—making it clear that these are the three focuses of the book as well as the core topics of statistics. [...] This third edition will no doubt be a popular textbook again for introductory courses. The online resources are helpful. It would be suitable for a one-year course so that the three parts, variability, probability, and inference, can be completely covered in sequence, providing a comprehensive understanding of concepts in biostatistics. [...] Overall, I highly recommend this textbook and congratulate the authors on writing a wonderful book again."
-Chuhsing Kate Hsiao in Biometrics, June 2023