Principles of Food Toxicology: 2nd Edition (Hardback) book cover

Principles of Food Toxicology

2nd Edition

By Tõnu Püssa

CRC Press

414 pages | 69 B/W Illus.

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pub: 2013-08-20
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Description

Following in the tradition of the popular first edition, Principles of Food Toxicology, Second Edition integrates the general principles of toxicology with a systematic characterization of the most important food-borne toxicants. Ideal as a textbook in a food toxicology course, and also as a monograph dealing with principles of food toxicology as the whole, and, due to sufficiently increased number of references, a source of elaborated scientific information, the second edition has been significantly revised and updated with new theories, opinions, and methods. It also provides expanded coverage of entry and absorption of foreign substances, carcinogenicity, reproductive and developmental toxicology, multi-organ toxicity, and flavor enhancers.

See What’s New in the Second Edition:

  • Role of lymph in transport of xenobiotics
  • Reproductive and developmental toxicity, risk-benefit analysis
  • Trans fatty acids
  • Soybean as a source of possible toxicants
  • Aluminum from cookware
  • Glutamates
  • New chapter on food adulteration
  • Updated and additional references

The book introduces the principles of toxicology at the molecular, cellular, and organism level. It provides a moderately rigorous treatment of biochemistry and chemistry with explanations of the mechanisms of toxic effect and medicinal consequences. The book arms toxicologists against new challenges in food safety brought on by long-term and often hard-to-diagnose effects of plant and animal toxicants that have already developed extensively by the time of discovery.

Table of Contents

Basics of Toxicology Connected to Food

Introduction

What is Toxicology?

Short History of Toxicology

Toxicity, Dose, and Response

Integrated Effect of Toxic Substances

Classification of Toxicants

Some Toxicology-Related Principles of Basics of Cell Biology and Biochemistry

References

Routes of Xenobiotics in an Organism

Entry and Absorption of Foreign Substances

Distribution of Xenobiotics in an Organism

Metabolism of Xenobiotics

Elimination of Xenobiotics and their Metabolites from Organism

Biomagnification

Antidotes

References

Toxic Response

Variability in Toxic Response

Physiological Classification of Toxic Responses

Molecular Mechanisms of Toxicity

Biomarkers of Toxic Effect

References

Analytical Toxicology: Determination of Foreign Compounds

Introduction

Sample Preparation

Mouse Bioassay: Functional Analysis

Biological Methods: Biosensors

Immunochemical Methods: Immunosensors

. Spectrophotometric (Colorimetric) Methods

Electrophoretic Methods

Chromatographic Methods

Detectors

References

Evaluation of Toxicity of Substances

Epidemiological Studies

Animal Tests

Cell-Culture Tests—Elaboration of Alternative Methods

Computer Calculations

Acute Toxicity Tests

Subacute/Chronic Toxicity Tests

Chronic Toxicity Tests

Specific Toxicity Tests

References

Toxicological Safety and Risk Analysis

Toxicological Safety

Risk Assessment

Risk.Benefit Analysis

References

MAIN GROUPS OF FOOD-BORNE TOXICANTS

Endogenous Plant Toxicants

Lectins or Hemagglutinins

Enzyme Inhibitors

Alkaloids

Cyanogenic Glycosides. Toxicity Mechanisms of HCN

Phytoestrogens

Glucosinolates

Coumarin

Thujones

Toxic Amino Acids

Toxic Lipids

Oxalates

Fluoroacetates

Bracken Toxins

Saponins

Grayanotoxin

Soybean as a Potential Source of Versatile Toxicants

Mushroom Toxins

Miscelleaneous

Genetically Modified Plants

References

Geochemical Pollutants that Plants Absorb from Soil

Arsenic

Selenium

Fluorine

References

Environmental Pollutants

Toxic Elements

Radionuclides

Polychlorinated Biphenyls (PCB)

Polychlorinated Dibenzodioxins and Dibenzofurans

References

Mycotoxins

Overview

Aflatoxins

Ochratoxins

Sterigmatocystin

Zearalenone

Fumonisins

Trichothecenes

Patulin

Citrinin and Citreoviridin

Ergot Toxins

Other Mycotoxins

Combined Toxicity of Mycotoxins

References

Animal Endogenous Poisons

Prions

Lactose

Phytanic Acid

Avidin

Vitamins of Animal Origin

References

Food Toxicants from Aquatic Animals

Shellfish Toxicants

Fish Toxins

References

Pesticide Residues

Overview

Insecticides

Herbicides

Fungicides

References

Veterinary Drugs and Feed Additives

Antibiotics

Hormones

Other Veterinary Drugs

References

Toxicants Unintentionally Entering Food During Processing, Storage, and Digestion of Food

General

Polycyclic Aromatic Hydrocarbons

Alcohols

Bacterial toxins

Biogenic Vasoactive Amines

Nitrates, Nitrites and Nitrosoamines

Acrylamide and 5-Hydroxymethylfurfural

Trans Fatty Acids

Toxic Oxidation Products of PUFAs

Chlorinated Propanols

Food Contact Materials

References

Food Additives

Traditional food additives

Functional additives

References

Vitamins

General

Vitamin A. Phenomenon of smokers

Vitamin D

Vitamin E

Vitamin K

Vitamin B2

Vitamin B6

Vitamin C

Vitamin B3

Diagnosing and Therapy of Vitamin Intoxications

References

Food Adulterations

What is Food Adulteration?

Melamime and Cyanuric Acid

AnisatineToxic Oil Syndrome

Epidemic Dropsy

References

Subject Categories

BISAC Subject Codes/Headings:
MED096000
MEDICAL / Toxicology
TEC012000
TECHNOLOGY & ENGINEERING / Food Science