This book represents a comprehensive update on pulmonary surfactant by merging classical knowledge with new information. Topics include surfactant secretion and alveolar processing and recycling; physical bases and different theoretical models of the physiological mechanism for pulmonary surfactant action; recent findings on surfactant-like material in other organs; developmental processes and multifactorial regulation; etiology and physiopathology of neonatal respiratory distress; and modern methods for functional explorations of the lung in neonates and experimental models in animals. The book also contains a discussion on the management of hyaline membrane disease, from both the experimental and clinical points of view.
Table of Contents
Pulmonary Surfactant-An Overview (Jacques R. Bourbon). The Type II Pneumocyte (Léa Marin). Nature, Function, and Biosynthesis of Surfactant Lipids (Jacques R. Bourbon). Structure, Function, and Regulation of Pulmonary Surfactant Proteins (Jeffrey A. Whitsett and Timothy E. Weaver). The Biology of the Surfactant-Associate Proteins (Jeanne M. Snyder). Comparative Aspects of Pulmonary Surfactant (Jacques R. Bourbon). Secretion, Alveolar Processing, and Turnover of Pulmonary Surfactant (Jacques R. Bourbon). Physiological Mechanisms for the Action of Pulmonary Surfactant (Brian A. Hills). Role of Surfactant in Other Organs (Brian A. Hills). Developmental Aspects of the Alveolar Epithelium and the Pulmonary Surfactant System (Jacques R. Bourbon and Caroline Fraslon). Fibroblast Pneumonocyte Factor (Barry T. Smith and Martin Post). Etiology of Neonatal Respiratory Distress Syndrome and the Assessment of Lung Maturity (Michel Dehan, Jeanne Francoual, M.C. Imbert, and Benoit Denizot). Functional Exploration of the Lung in Neonatal Respiratory Distress Syndrome: Use of Animal Models for the Study of Respiratory Distress (Claude Gaultier). Exogenous Surfactant in the Management of Hyaline Membrane Disease (Herve Walti, Michèle Couchard, and Jean-Pierre Relier). Index.
Jacques Bourbon, Ph.D., is Research Director at the Center for Cellular Biology of the Centre National de la Recherche Scientifique (C.N.R.S.) at Ivry-sur-Seine, France., Dr. Bourbon obtained his Maîtrise (B.Sc. degree) in Physiology at the Faculty of Sciences of Paris, France, in 1969 and a Doctorat es Sciences (doctoral degree) in Natural Sciences at the University Pierre et Marie Curie, Paris, in 1980. He has worked under the direction of Professor Alfred Jost at the Comparative Physiology Laboratory, University Pierre et Marie Curie, Paris, and at the Developmental Physiology Laboratory, Collège de France, Paris., Dr. Bourbon is a member of the European Tissue Culture Association and the European Respiratory Society. He has been the recipient of research grants from the Institut National de la Santé et de la Recherche Médicale (I.N.S.E.R.M.). He has been Research Associate, Department of Pediatrics, at the University of Wisconsin at Madison and Visiting Assistant Professor, Department of Biochemistry, at the University of Texas at Dallas, for which he also received a grant from the French Ministry of Foreign Affairs., Dr. Bourbon has published 40 scientific papers, is coauthor of 3 books, and has been invited to give lectures and seminars at universities and other scientific institutions from Europe and the U.S. His current research interests are in differentiation and functional maturation of lung cells in keeping with problems linked to neonatal pulmonary immaturity.