1st Edition

Advanced Pharmaceutics
Physicochemical Principles

ISBN 9780849317293
Published March 17, 2004 by CRC Press
512 Pages - 270 B/W Illustrations

USD $280.00

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Book Description

Discussing a comprehensive range of topics, Advanced Pharmaceutics: Physicochemical Principles reviews all aspects of physical pharmacy. The book explains the basic, mechanistic, and quantitative interpretation skills needed to solve physical pharmacy related problems. The author supplies a strong fundamental background and extensively covers thermodynamics, ionic equilibria, solutions and distribution, surface chemistry and colloids, kinetics, diffusion, and polymer science. He outlines the latest research on diffusion through a membrane and the use of polymers in dosage forms.

Packed with formulae and models, the book demonstrates the development of each and then describes the use of those models for a variety of formulation situations. The author's detailed explanation of the evolution of the formulae provides a clear understanding of when and how they are used. This bottom-up approach delineates the evolution of the formulae and gives a clear understanding of when and how they should be used. The book provides an in-depth review and analysis of dosage form design criteria that you can rapidly implement in your day-to-day work.

Table of Contents

Ideal Gases
Real Gases
Free Energy

Strong Acids and Bases
Monoprotic Weak Acids and Weak Bases
Polyprotic Weak Acids and Weak Bases
Sparingly Soluble Salts

Solutions of Solids and Non-volatile Liquids in Liquids
Solutions of Volatile Liquids in Liquids
Solutions of Gases in Liquids (Henry's Law)
Colligative Properties
Distribution Law (Partition Coefficient)

Adsorption from Solutions
Liquid-Liquid Systems (Emulsions)
Solid-Liquid Systems (Suspensions)

Pathways of Drug Degradation
Single and Multiple Reactions, Elementary Reactions, Molecularity, and Order of Reactions
Irreversible Reactions
Determination of the Order of Reaction and Its Rate Constant
Other Irreversible Reactions
Reversible Reactions
Reversible and Series Reactions (Eigenvalue Method)
Use of Laplace Transform for Differential Rate Equations
Enzyme-Substrate Reactions
Acid-Base Catalyzed Degradation Kinetics
Oxidation (Free Radical Reaction)
Degradation Kinetics in Inclusion Complexes, Micelles, and Liposomes
Temperature Effects on Reaction Rate Constants

Diffusion Through a Membrane
Diffusion in a Monolithic Matrix
Diffusion in a Membrane-Matrix System
Diffusion During the Swelling of Matrix
Diffusion in a Matrix Erosion/Degradation
Diffusion in a Matrix Swelling/Erosion
Diffusion with Chemical Reaction in a Membrane
Surface Area and Concentration Gradient Systems
Osmotically Controlled Systems

Classification of Polymers
Molecular Weight and Molecular Weight Distribution of Polymers
Characterization of Polymers
Polymer Synthesis
Natural Polymers and Their Modification

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"The book contains 22 chapters and covers a very wide range of topics. With a few exceptions, these contributions are from leaders in the field of drug delivery. The ideas and results presented are all extremely creative and interesting. This reviewer would recommend this book as it presents a broad selection of some very interesting directions that polymer drug delivery will be taking in the near future."
-Lisa Brannon-Peppas, PhD, The Department of Biomedical Engineering, The University of Texas at Austin