1st Edition

Advanced Pharmaceutics Physicochemical Principles

By Cherng-ju Kim Copyright 2004
    512 Pages 270 B/W Illustrations
    by CRC Press

    Discussing a comprehensive range of topics, Advanced Pharmaceutics: Physicochemical Principles reviews all aspects of physical pharmacy. The book explains the basic, mechanistic, and quantitative interpretation skills needed to solve physical pharmacy related problems. The author supplies a strong fundamental background and extensively covers thermodynamics, ionic equilibria, solutions and distribution, surface chemistry and colloids, kinetics, diffusion, and polymer science. He outlines the latest research on diffusion through a membrane and the use of polymers in dosage forms.

    Packed with formulae and models, the book demonstrates the development of each and then describes the use of those models for a variety of formulation situations. The author's detailed explanation of the evolution of the formulae provides a clear understanding of when and how they are used. This bottom-up approach delineates the evolution of the formulae and gives a clear understanding of when and how they should be used. The book provides an in-depth review and analysis of dosage form design criteria that you can rapidly implement in your day-to-day work.

    Ideal Gases
    Real Gases
    Free Energy

    Strong Acids and Bases
    Monoprotic Weak Acids and Weak Bases
    Polyprotic Weak Acids and Weak Bases
    Sparingly Soluble Salts

    Solutions of Solids and Non-volatile Liquids in Liquids
    Solutions of Volatile Liquids in Liquids
    Solutions of Gases in Liquids (Henry's Law)
    Colligative Properties
    Distribution Law (Partition Coefficient)

    Adsorption from Solutions
    Liquid-Liquid Systems (Emulsions)
    Solid-Liquid Systems (Suspensions)

    Pathways of Drug Degradation
    Single and Multiple Reactions, Elementary Reactions, Molecularity, and Order of Reactions
    Irreversible Reactions
    Determination of the Order of Reaction and Its Rate Constant
    Other Irreversible Reactions
    Reversible Reactions
    Reversible and Series Reactions (Eigenvalue Method)
    Use of Laplace Transform for Differential Rate Equations
    Enzyme-Substrate Reactions
    Acid-Base Catalyzed Degradation Kinetics
    Oxidation (Free Radical Reaction)
    Degradation Kinetics in Inclusion Complexes, Micelles, and Liposomes
    Temperature Effects on Reaction Rate Constants

    Diffusion Through a Membrane
    Diffusion in a Monolithic Matrix
    Diffusion in a Membrane-Matrix System
    Diffusion During the Swelling of Matrix
    Diffusion in a Matrix Erosion/Degradation
    Diffusion in a Matrix Swelling/Erosion
    Diffusion with Chemical Reaction in a Membrane
    Surface Area and Concentration Gradient Systems
    Osmotically Controlled Systems

    Classification of Polymers
    Molecular Weight and Molecular Weight Distribution of Polymers
    Characterization of Polymers
    Polymer Synthesis
    Natural Polymers and Their Modification


    Cherng-ju Kim

    "The book contains 22 chapters and covers a very wide range of topics. With a few exceptions, these contributions are from leaders in the field of drug delivery. The ideas and results presented are all extremely creative and interesting. This reviewer would recommend this book as it presents a broad selection of some very interesting directions that polymer drug delivery will be taking in the near future."
    -Lisa Brannon-Peppas, PhD, The Department of Biomedical Engineering, The University of Texas at Austin