Advanced Pharmaceutics: Physicochemical Principles, 1st Edition (Hardback) book cover

Advanced Pharmaceutics

Physicochemical Principles, 1st Edition

By Cherng-ju Kim

CRC Press

512 pages | 270 B/W Illus.

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Hardback: 9780849317293
pub: 2004-03-17
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Discussing a comprehensive range of topics, Advanced Pharmaceutics: Physicochemical Principles reviews all aspects of physical pharmacy. The book explains the basic, mechanistic, and quantitative interpretation skills needed to solve physical pharmacy related problems. The author supplies a strong fundamental background and extensively covers thermodynamics, ionic equilibria, solutions and distribution, surface chemistry and colloids, kinetics, diffusion, and polymer science. He outlines the latest research on diffusion through a membrane and the use of polymers in dosage forms.

Packed with formulae and models, the book demonstrates the development of each and then describes the use of those models for a variety of formulation situations. The author's detailed explanation of the evolution of the formulae provides a clear understanding of when and how they are used. This bottom-up approach delineates the evolution of the formulae and gives a clear understanding of when and how they should be used. The book provides an in-depth review and analysis of dosage form design criteria that you can rapidly implement in your day-to-day work.


"The book contains 22 chapters and covers a very wide range of topics. With a few exceptions, these contributions are from leaders in the field of drug delivery. The ideas and results presented are all extremely creative and interesting. This reviewer would recommend this book as it presents a broad selection of some very interesting directions that polymer drug delivery will be taking in the near future."

-Lisa Brannon-Peppas, PhD, The Department of Biomedical Engineering, The University of Texas at Austin

Table of Contents


Ideal Gases

Real Gases


Free Energy


Strong Acids and Bases

Monoprotic Weak Acids and Weak Bases

Polyprotic Weak Acids and Weak Bases

Sparingly Soluble Salts


Solutions of Solids and Non-volatile Liquids in Liquids

Solutions of Volatile Liquids in Liquids

Solutions of Gases in Liquids (Henry's Law)

Colligative Properties

Distribution Law (Partition Coefficient)


Adsorption from Solutions

Liquid-Liquid Systems (Emulsions)

Solid-Liquid Systems (Suspensions)


Pathways of Drug Degradation

Single and Multiple Reactions, Elementary Reactions, Molecularity, and Order of Reactions

Irreversible Reactions

Determination of the Order of Reaction and Its Rate Constant

Other Irreversible Reactions

Reversible Reactions

Reversible and Series Reactions (Eigenvalue Method)

Use of Laplace Transform for Differential Rate Equations

Enzyme-Substrate Reactions

Acid-Base Catalyzed Degradation Kinetics

Oxidation (Free Radical Reaction)

Degradation Kinetics in Inclusion Complexes, Micelles, and Liposomes

Temperature Effects on Reaction Rate Constants



Diffusion Through a Membrane

Diffusion in a Monolithic Matrix

Diffusion in a Membrane-Matrix System

Diffusion During the Swelling of Matrix

Diffusion in a Matrix Erosion/Degradation

Diffusion in a Matrix Swelling/Erosion

Diffusion with Chemical Reaction in a Membrane

Surface Area and Concentration Gradient Systems

Osmotically Controlled Systems


Classification of Polymers

Molecular Weight and Molecular Weight Distribution of Polymers

Characterization of Polymers

Polymer Synthesis

Natural Polymers and Their Modification


Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Pharmacology
MEDICAL / Pharmacy