1st Edition

Metal Toxicology Handbook

Edited By Debasis Bagchi, Manashi Bagchi Copyright 2021
    510 Pages 44 B/W Illustrations
    by CRC Press

    Heavy metals and metalloids, singly or in combination, induce toxic manifestations either through acute or chronic pathology. In particular, long-term chronic exposure to diverse heavy metals and metalloids to humans and animals can lead to numerous physical, muscular, neurological, nephrological, and diverse degenerative diseases and dysfunctions, including multiple sclerosis, muscular dystrophy, Parkinson’s and Alzheimer’s diseases, cardiovascular disorders, and several others.

    Recognized heavy metals such as lead, mercury, arsenic, cadmium, thallium, and hexavalent chromium are known for enormous toxicity. The immediate vital signs of acute heavy metal exposure include nausea, vomiting, diarrhea, and acute abdominal pain. Mercury has been identified as the most toxic heavy metal, and mercury poisoning is known as acrodynia or pink disease. Similarly, lead, another toxic heavy metal, was at one time an integral part of painting.

    Metal Toxicology Handbook further explains and discusses the varying attributes of metals, discussing toxicity, safety, and proper human utilization of metals. Beginning with a broad overview of metals, metalloids, redox biology, and neurodegeneration and going further into the roles, benefits, and toxicity of metals with each section, the text contains 28 chapters from eminent researchers and scientists in their respective fields and is a must-have for anyone researching the potential toxicity in metals.

    Key Features

    • Discusses the pathology of metal toxicity
    • Highlights the benefits of metals
    • Explains the mechanism and salient features of restoring metabolic homeostasis
    • Highlights dose-dependent beneficial and adverse effects of vanadium safety and toxicity

    The initial introductory section provides a broad overview of metals, metalloids, redox biology, and neurodegeneration. The second section discusses the pathology of metal toxicity in two chapters, while the third section highlights the mechanism and salient features of restoring metabolic homeostasis in two chapters. The fourth section demonstrates the aspect of radionuclides toxicity. In a change of pace, the fifth section discusses the benefits of metals in four chapters. The sixth section, titled "Toxic Manifestations by Diverse Heavy Metals and Metalloids," provides fourteen chapters that discuss the toxicological mechanism and manifestation of individual metals.

    The editors have crafted a commentary titled "A Treatise on Metal Toxicity" and summarized a vivid scenario of metal toxicity and its consequences.

    Part I: Introduction: Metals, Metalloids, Redox Biology, and Neurodegeneration

    1. Role of Metals and Metalloids in Redox Biology

    [Amit Madeshiya, Pradipta Banerjee, Suman Santra, Nandini Ghosh, Sayantani Karmakar, Debasis Bagchi, Sashwati Roy, and Amitava Das]

    2. Role of Metals in Neurodegeneration

    [Abhai Kumar, Smita Singh, and Rameshwar Nath Chaurasia]

    Part II: Pathology of Metal Toxicity

    3. Pathological Manifestations and Mechanisms of Metal Toxicity

    [Odete Mendes and Chidozie Amuzie]

    4. An Overview of Heavy Metal Research in Traditional Chinese Medicine

    [Yu Xu, Ning Wang, and Yibin Feng]

    Part III: Mechanisms of Restoring Metabolic Homeostasis

    5. Development and Utilization of a Novel Prodosomed-Electrolyte and Phytochemical Formulation Technology to Restore Metabolic Homeostasis

    [Bernard W. Downs, Manashi Bagchi, Bruce S. Morrison, Jeffrey Galvin, Steve Kushner, and Debasis Bagchi]

    6. Gut Microbiome and Heavy Metals

    [Ashfaque Hossain, Muhammad Manjurul Karim, Tania Akter Jhuma, and Godfred A. Menezes]

    Part IV: Radionuclides Toxicity

    7. A Review on Radionuclide Toxicity

    [Fco. Javier Guillén Gerada and José Ángel Corbacho Merino]

    Part V: Benefits of Metals

    8. Contribution of Bioavailable Silicon in Human Health

    [Keith Robert Martin]

    9. Benefits of Trivalent Chromium in Human Nutrition?

    [John B. Vincent]

    10. Trivalent Chromium: A Vital Insulin Sensitizer

    [Harry G. Preuss and Debasis Bagchi]

    11. Differential Impact of Organic Vanadium Compounds on Human Health: Deficiency States, Toxic Effects, and Potential Therapeutic Use

    [Satinath Mukhopadhayay and Bidisha Mukherjee]

    12. Vanadium—Speciation Chemistry Can Be Important When Assessing Health Effects on Living Systems

    [Debbie C. Crans, Kahoana Postal, and Judith A. MacGregor]

    Part VI: Toxic Manifestations by Diverse Heavy Metals and Metalloids

    13. Clinical Toxicology of Copper: Source, Toxidrome, Mechanism of Toxicity and Management

    [Sonal Sekhar Miraj and Mahadev Rao]

    14. Cadmium Exposure and Toxicity

    [Soisungwan Satarug and Kenneth R. Phelps]

    15. Cobalt Toxicity and Human Health

    [Md. Hafiz Uddin and Marufa Rumman]

    16. Cobalt Toxicity

    [Muhammad Umar, Ayyaz Sultan, Noman Jahangir, and Zobia Saeed]

    17. Iron-Siderophore and Tumorigenesis: Molecular Insight and Therapeutic Targets

    [Sayantan Maitra and Dibyendu Dutta]

    18. Clinical Toxicology of Iron: Source, Toxidrome, Mechanism of Toxicity, and Management

    [Shilia Jacob Kurian, Sonal Sekhar Miraj, Ahmed Alshrief, Sreedharan Nair, and Mahadev Rao]

    19. Vanadium Toxicity Revisited: Striking the Right Balance between Potential New Generation Therapeutics and Adverse Side Effects

    [Rituparna Ghosh, Ahana Das, Arnab Bandyopadhyay, Rajib Majumder, and Samudra Prosad Banik]

    20. The Ubiquitous Lead—Biological Effects, Toxicity, and Management

    [Sreejayan Nair and Debasis Bagchi]

    21. Lead Toxicity: An Overview of Its Pathophysiology and Intervention Strategies

    [Rokeya Pervin, Md. Akil Hossain, Dipti Debnath, and Mohiuddin Ahmed Bhuiyan]

    22. Arsenic Toxicity: Source, Mechanism, Global Health Complication, and Possible Way to Defeat

    [Dipti Debnath, Biddut Deb Nath, Rokeya Pervin, and Md. Akil Hossain]

    23. Clinical Toxicology of Mercury: Source, Toxidrome, Mechanism of Toxicity, and Management

    [Sonal Sekhar Miraj, Pooja Gopal Poojari, Girish Thunga P, and Mahadev Rao]

    24. An Overview of Tungsten Toxicity

    [Ola Wasel and Jennifer L. Freeman]

    25. Boron Toxicity: An Insight on Its Influence on Wheat Growth

    [Anamika Pandey, Mohd. Kamran Khan, Mehmet Hamurcu, Fatma Gokmen Yilmaz, and Sait Gezgin]

    26. Diversity of Mechanisms for Boron Toxicity in Mammals

    [Diana Rodríguez-Vera, Antonio Abad-García, Mónica Barrón-González, Julia J. Segura-Uribe, Eunice D. Farfán-García, and Marvin A. Soriano-Ursúa]

    27. Lithium: Is It Good or Bad for Plant Growth?

    [Mohsin Tanveer and Lei Wang]

    28. An Overview of Nickel Toxicity in Plants

    [Mohsin Tanveer]

    Commentary: A Treatise on Metal Toxicology


    Debasis Bagchi, Manashi Bagchi