Micronutrients and Brain Health: 1st Edition (Hardback) book cover

Micronutrients and Brain Health

1st Edition

Edited by Lester Packer, Helmut Sies, Manfred Eggersdorfer, Enrique Cadenas

CRC Press

460 pages | 6 Color Illus. | 44 B/W Illus.

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pub: 2009-10-06
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Description

Micronutrients and Brain Health addresses cutting-edge research related to processes of oxidative stress that affect brain function, an area of increasing significance for those concerned and involved with public health and translational medicine. Edited by four leading micronutrient researchers, the book brings together the investigative work of more than 70 leading researchers from across the world. Chapters identify brain-specific micronutrients that support function as well as the molecular mechanisms underlying their neuroprotectant activity. These explore age-related metabolic pathways, mitochondrial nutrients, neurodegeneration and micronutrients, cell signaling, and neuronal functions. General chapters are included on brain structure, function, and metabolism, while several other chapters are devoted to the role of specific micronutrients. The book explores how brain micronutrients are found to be both metabolic and redox regulators, thereby establishing a cross-talk between the major pathways involved in modulation of cell signaling and gene expression. Specific areas of research covered include:

  • Uses of nutritional interventions to target age-related neuronal and behavioral deficits
  • Effects of various micronutrients on Alzheimer’s disease, including lipoic acid, green tea, and Ginkgo biloba extracts
  • Nutrients specific to essential mitochondrial functions
  • Cognitive and behavioral consequences of iron deficiency with specific emphasis on women of reproductive age
  • Omega-3 fatty acids and their relation to brain function in the elderly
  • Challenges inherent in the development of neuroprotective-neurorescue drugs

This book belongs to the groundbreaking CRC Press Series on Oxidative Stress and Disease. The series now includes more than two dozen volumes that address increasing evidence regarding the multiple ways that oxidative stress initiates and accelerates disease mechanisms. Most importantly, this book, like the series, offers invaluable information regarding nutritional and lifestyle choices, and pharmaceutical interventions that can be employed to prevent, control, and even ameliorate disease processes attributed to oxidative stress.

Table of Contents

Neuroprotection after Cardiac Arrest by Avoiding Acute Hyperoxia and by Antioxidant Genomic Postconditioning, G. Fiskum and R.E. Rosenthal

The Neuroprotective Role of Micronutrients in Parkinson’s; Kristen Malkus, Elpida Tsika, and Harry Ischiropoulos Phytoestrogens and Brain Health, L. Zhao and R. Diaz Brinton

Food Antioxidants and Alzheimer’s Disease, E. Ramiro-Puig, M. Castell, A. McShea, G. Perry, M.A. Smith, and G. Casadesus

Micronutrient Antioxidants, Cognition, and Neuropathology: A Longitudinal Study in the Canine Model of Human Aging, W.O. Opii and E. Head

Excitatory Amino Acids, S-nitrosylation, and Protein Misfolding in Neurodegenerative Disease: Protection by Memantine and NitroMemantine at NMDA-Gated Channels, T. Nakamura and S.A. Lipton

Cognitive and Behavioral Consequences of Iron Deficiency in Women of Reproductive Age, L.E. Murray-Kolb

Micronutrient Needs of the Developing Brain: Priorities and Assessment, A.J. Fuglestad, S.E. Ramel, and M.K. Georgieff

Therapeutics of Alzheimer’s Disease Based on Metal Bioavailability, S.S. Mok and A.I. Bush

Lipoic Acid as a Novel Treatment for Mild Cognitive Impairment and Early-Stage Alzheimer’s Disease, A. Maczurek, M. Krautwald, M. Steele, K. Hager, M. Kenklies, M. Sharman, R. Martins, J. Engel, D. Carlson, and G. Münch

Zinc and the Cytoskeleton in Neuronal Signaling, G.G. Mackenzie and P.I. Oteiza

Tocotrienol Neuroprotection: The Most Potent Biological Function of All Natural Forms of Vitamin E, C.K. Sen, S. Khanna, and S. Roy

Fruits, Nuts, and Brain Aging: Nutritional Interventions Targeting Age-Related Neuronal and Behavioral Deficits, J.A. Joseph, B. Shukitt-Hale, and L.M. Willis

Modulation of Multiple Pathways Involved in the Maintenance of Neuronal Function, F.P. Maher

Dietary Flavonoids as Neuroprotective Agents, J.P.E. Spencer, D. Vauzour, K. Vafeiadou, and A. Rodriguez Mateos

Actions of Bioactive Phytochemicals in Cell Function and Alzheimer’s Disease Pathology, R.E. Hartman

Does Ginkgo biloba Extract Exert an Effect on Alzheimer’s Disease Progression, Y. Christen

Green Tea Polyphenols Protect Neurons against Alzheimer’s Disease and Parkinson’s Disease, B. Zhao

Transport of Flavonoids into the Brain, P.E. Milburg

Prevention and Treatment of Neurodegenerative Diseases by Spice-Derived Phytochemicals, B.B. Aggarwal, K.B. Harikumar, and S. Dey

Neurohormetic Properties of the Phytochemical Resveratrol, A.L. Holme and S. Pervaiz

Sirtuin and Resveratrol, A. Camins, C. Pelegri, J. Vilaplana, R. Cristofol, C. Sanfeliu, and M. Pallàs

Acetyl-l-Carnitine and Ferulic Acid Action in Aging and Neurodegenerative Diseases, R.A. Sowell, C.D. Aluise, and D.A. Butterfield

Evidence Required for Causal Inferences about Effects of Micronutrient Deficiencies during Development on Brain Health: DHA, Choline, Iron, and Vitamin D, J.C. McCann and B.N. Ames

Omega-3 Fatty Acids and Brain Function in Older People, R. Uauy and A.D. Dangour

Iron and Monoamine Oxidase in Brain Function and Dysfunction: Development of Neuroprotective-Neurorescue Drugs, O. Weinreb, T. Amit, S. Mandel, and M.B.H. Youdim

Antioxidative Defense of Brain Microglial Cells, R. Dringen and J. Hirrlinger

Branched-Chain Amino Acids and Brain Metabolism, R. Murín and B. Hamprecht

About the Series

Oxidative Stress and Disease

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
MED060000
MEDICAL / Nutrition
SCI017000
SCIENCE / Life Sciences / Cytology
SCI086000
SCIENCE / Life Sciences / General
SCI089000
SCIENCE / Life Sciences / Neuroscience