1st Edition

Micronutrients and Brain Health

    460 Pages 6 Color & 44 B/W Illustrations
    by CRC Press

    Micronutrients and Brain Health addresses cutting-edge research related to processes of oxidative stress that affect brain function, an area of increasing significance for those concerned and involved with public health and translational medicine. Edited by four leading micronutrient researchers, the book brings together the investigative work of more than 70 leading researchers from across the world. Chapters identify brain-specific micronutrients that support function as well as the molecular mechanisms underlying their neuroprotectant activity. These explore age-related metabolic pathways, mitochondrial nutrients, neurodegeneration and micronutrients, cell signaling, and neuronal functions. General chapters are included on brain structure, function, and metabolism, while several other chapters are devoted to the role of specific micronutrients. The book explores how brain micronutrients are found to be both metabolic and redox regulators, thereby establishing a cross-talk between the major pathways involved in modulation of cell signaling and gene expression. Specific areas of research covered include:

    • Uses of nutritional interventions to target age-related neuronal and behavioral deficits
    • Effects of various micronutrients on Alzheimer’s disease, including lipoic acid, green tea, and Ginkgo biloba extracts
    • Nutrients specific to essential mitochondrial functions
    • Cognitive and behavioral consequences of iron deficiency with specific emphasis on women of reproductive age
    • Omega-3 fatty acids and their relation to brain function in the elderly
    • Challenges inherent in the development of neuroprotective-neurorescue drugs

    This book belongs to the groundbreaking CRC Press Series on Oxidative Stress and Disease. The series now includes more than two dozen volumes that address increasing evidence regarding the multiple ways that oxidative stress initiates and accelerates disease mechanisms. Most importantly, this book, like the series, offers invaluable information regarding nutritional and lifestyle choices, and pharmaceutical interventions that can be employed to prevent, control, and even ameliorate disease processes attributed to oxidative stress.

    Neuroprotection after Cardiac Arrest by Avoiding Acute Hyperoxia and by Antioxidant Genomic Postconditioning, G. Fiskum and R.E. Rosenthal
    The Neuroprotective Role of Micronutrients in Parkinson’s; Kristen Malkus, Elpida Tsika, and Harry Ischiropoulos Phytoestrogens and Brain Health, L. Zhao and R. Diaz Brinton
    Food Antioxidants and Alzheimer’s Disease, E. Ramiro-Puig, M. Castell, A. McShea, G. Perry, M.A. Smith, and G. Casadesus
    Micronutrient Antioxidants, Cognition, and Neuropathology: A Longitudinal Study in the Canine Model of Human Aging, W.O. Opii and E. Head
    Excitatory Amino Acids, S-nitrosylation, and Protein Misfolding in Neurodegenerative Disease: Protection by Memantine and NitroMemantine at NMDA-Gated Channels, T. Nakamura and S.A. Lipton
    Cognitive and Behavioral Consequences of Iron Deficiency in Women of Reproductive Age, L.E. Murray-Kolb
    Micronutrient Needs of the Developing Brain: Priorities and Assessment, A.J. Fuglestad, S.E. Ramel, and M.K. Georgieff
    Therapeutics of Alzheimer’s Disease Based on Metal Bioavailability, S.S. Mok and A.I. Bush
    Lipoic Acid as a Novel Treatment for Mild Cognitive Impairment and Early-Stage Alzheimer’s Disease, A. Maczurek, M. Krautwald, M. Steele, K. Hager, M. Kenklies, M. Sharman, R. Martins, J. Engel, D. Carlson, and G. Münch
    Zinc and the Cytoskeleton in Neuronal Signaling, G.G. Mackenzie and P.I. Oteiza
    Tocotrienol Neuroprotection: The Most Potent Biological Function of All Natural Forms of Vitamin E, C.K. Sen, S. Khanna, and S. Roy
    Fruits, Nuts, and Brain Aging: Nutritional Interventions Targeting Age-Related Neuronal and Behavioral Deficits, J.A. Joseph, B. Shukitt-Hale, and L.M. Willis
    Modulation of Multiple Pathways Involved in the Maintenance of Neuronal Function, F.P. Maher
    Dietary Flavonoids as Neuroprotective Agents, J.P.E. Spencer, D. Vauzour, K. Vafeiadou, and A. Rodriguez Mateos
    Actions of Bioactive Phytochemicals in Cell Function and Alzheimer’s Disease Pathology, R.E. Hartman
    Does Ginkgo biloba Extract Exert an Effect on Alzheimer’s Disease Progression, Y. Christen
    Green Tea Polyphenols Protect Neurons against Alzheimer’s Disease and Parkinson’s Disease, B. Zhao
    Transport of Flavonoids into the Brain, P.E. Milburg
    Prevention and Treatment of Neurodegenerative Diseases by Spice-Derived Phytochemicals, B.B. Aggarwal, K.B. Harikumar, and S. Dey
    Neurohormetic Properties of the Phytochemical Resveratrol, A.L. Holme and S. Pervaiz
    Sirtuin and Resveratrol, A. Camins, C. Pelegri, J. Vilaplana, R. Cristofol, C. Sanfeliu, and M. Pallàs
    Acetyl-l-Carnitine and Ferulic Acid Action in Aging and Neurodegenerative Diseases, R.A. Sowell, C.D. Aluise, and D.A. Butterfield
    Evidence Required for Causal Inferences about Effects of Micronutrient Deficiencies during Development on Brain Health: DHA, Choline, Iron, and Vitamin D, J.C. McCann and B.N. Ames
    Omega-3 Fatty Acids and Brain Function in Older People, R. Uauy and A.D. Dangour
    Iron and Monoamine Oxidase in Brain Function and Dysfunction: Development of Neuroprotective-Neurorescue Drugs, O. Weinreb, T. Amit, S. Mandel, and M.B.H. Youdim
    Antioxidative Defense of Brain Microglial Cells, R. Dringen and J. Hirrlinger
    Branched-Chain Amino Acids and Brain Metabolism, R. Murín and B. Hamprecht


    Lester Packer, Helmut Sies, Manfred Eggersdorfer, Enrique Cadenas