1st Edition


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ISBN 9780824726638
Published May 23, 2005 by CRC Press
504 Pages 83 B/W Illustrations

USD $280.00

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Book Description

Nutritional genomics, also referred to as nutrigenomics, is considered one of the next frontiers in the post-genomic era. Its fundamental premise is that while alterations in gene expression or epigenetic phenomena can subvert a healthy phenotype into manifesting chronic disease, through the introduction of certain nutrients, this process can be reversed or modified. Employing state-of-the-art genomic and proteomic investigations that monitor the expression of thousands of genes in response to diet, nutrigenomics investigates the occurrence of relationship between dietary nutrients and gene expression.

Nutrigenomics was compiled to update the reader on recent advances in this emerging field. Over forty experts in nutrition, physiology, pathology, pharmacology, and the microbial sciences from all across the world present cutting-edge developments and emerging methods presently used in nutrigenomics. They include the latest studies and research on the role of oxidants, antioxidants, phytochemicals, and micronutrients in the modulation of gene expression affecting aging, immune function, carcinogenesis, and vascular health. As most human diseases are largely avoidable by lifestyle changes, this places nutrigenomics at the forefront of preventive medicine.

Table of Contents

Application of Nutrigenomics Tools to Analyze the Role of Oxidants and Antioxidants in Gene Expression, Gerald Rimbach and Sonia De Pascual-Teresa
Oxidative Stress and Human Genetic Variation, R. D. Gill-Garrison, J. L. Slater, and K. Grimaldi
Analysis of Microarray Data, Ken Mills
Oxidative Stress, Gene Expression, and Lifespan, Yoko Honda and Shuji Honda
Anti-Oxidant Modulation in Immune Function, Robert Francis Grimble
Concentration-Dependent Gene and Protein Expressions of Neuroprotective and Neurotoxic Activities of Antioxidants, Including Nutrients, Orly Weinreb, Silvia Mandel, and Moussa B. H. Youdim
Effects of Antioxidants on Gene Expression in Endothelial Cells, B. A. Nier, B. A. Ewins, S. G. Cremers, and Peter D. Weinberg
Fatty Acids, Gene Expression, and Coronary Heart Disease (CHD), Anne M. Minihane
Cell Regulatory Activity of Tocopherols and Tocotrienols, Cristina Rota, Anne M. Minihane, Peter D. Weinberg, Stefan Weber, John K. Lodge, Lester Packer, and Gerald Rimbach
Molecular Analysis of the Vitamin A Biosynthetic Pathway, Johannes von Lintig
Molecular Mechanisms Underlaying the Health Promoting Activity of Lycopene, Estibaliz Olano-Martin
Cellular Redox Activity and Molecular Functions of Ascorbic Acid, John K. Lodge
Cell Signaling Properties of a-Lipoic Acid: Implications in Type 2 Diabetes, Hadi Moini, Lester Packer, Kyung-Joo Cho, and An-Sik Chung
Dietary Isoflavones and Coronary Artery Disease-Proposed Molecular Mechanisms of Action, Aedin Cassidy and Sonia De Pascual-Teresa
Anti-Carcinogenic Properties of Soy Isoflavones, Max O. Bingham and Glenn R. Gibson
Effect of Ginkgo biloba Extract EGb 761on Differential Gene Expression in the Brain, Rainer Cermak and Siegfried Wolffram
Interactions of Flavonoids and Their Metabolites with Cell Signaling Cascades, Jeremy P. E. Spencer
Antioxidant and Gene Regulatory Properties of Procyanidins, R. Canali, R. Ambra, O. Gulati, and F. Virgili
Cell Signaling Properties of Inositol Hexaphosphate (IP6), Abulkalam M. Shamsuddin
Modulation of Gene Expression by Dietary Iron, Paul Sharp
Dietary Selenium and Gene Expression, Alexandra Fischer and Josef Pallauf
Modulation of Gene Expression by Dietary Zinc, Raymond K. Blanchard and Robert J. Cousins

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"The text is divided into 22 chapters written by experts in nutrition, physiology and pharmacology from several countries. The main issues reviewed are oxidants, antioxidants and gene expression, and relationships between gene expression and nutrient related diseases."
-Pediatric Endocrinology Reviews, Vol. 3, No. 2, Dec. 2005