Nutrigenomics  book cover
1st Edition


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ISBN 9780824726638
Published May 23, 2005 by CRC Press
504 Pages 83 B/W Illustrations

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Book Description

Nutritional genomics, also referred to as nutrigenomics, is considered one of the next frontiers in the post-genomic era. Its fundamental premise is that while alterations in gene expression or epigenetic phenomena can subvert a healthy phenotype into manifesting chronic disease, through the introduction of certain nutrients, this process can be reversed or modified. Employing state-of-the-art genomic and proteomic investigations that monitor the expression of thousands of genes in response to diet, nutrigenomics investigates the occurrence of relationship between dietary nutrients and gene expression.

Nutrigenomics was compiled to update the reader on recent advances in this emerging field. Over forty experts in nutrition, physiology, pathology, pharmacology, and the microbial sciences from all across the world present cutting-edge developments and emerging methods presently used in nutrigenomics. They include the latest studies and research on the role of oxidants, antioxidants, phytochemicals, and micronutrients in the modulation of gene expression affecting aging, immune function, carcinogenesis, and vascular health. As most human diseases are largely avoidable by lifestyle changes, this places nutrigenomics at the forefront of preventive medicine.

Table of Contents

Application of Nutrigenomics Tools to Analyse the Role of Oxidants and Antioxidants in Gene Expression. Oxidative Stress and Human Genetic Variation. Analysis of Micro Array Data. Oxidative Stress, Gene Expression and Lifespan. Antioxidant Modulation in Immune Function. Concentration Dependent Gene and Protein Expressions of Neuroprotective and Neurotoxic Activities of Antioxidants, Including Nutrients. Effects of Antioxidants on Gene Expression in Endothelial Cells. Fatty Acids, Gene Expression and Coronary Heart Disease (CHD). Cell Regulatory Activity of Tocopherols and Tocotrienols. Molecular Analysis of the Vitamin A Biosynthetic Pathway. Molecular Mechanisms Underlaying the Health Promoting Activity of Lycopene. Cellular Redox Activity and Molecular Functions of Ascorbic Acid. Cell Signaling Properties of a-Lipoic Acid: Implications in Type 2 Diabetes. Dietary Isoflavones and Coronary Artery Disease - Proposed Molecular Mechanisms of Action. Anti-Carcinogenic Properties of Soy Isoflavones. Effect of Ginkgo Biloba Extract Egb 761 on Differential Gene Expression in the Brain. Interactions of Flavonoids and Their Metabolites with Cell Signalling Cascades. Antioxidant and Gene Regulatory Properties of Procyanidins. Cell Signaling Properties of Inositol Hexaphosphate (IP6). Modulation of Gene Expression by Dietary Iron. Dietary Selenium and Gene Expression. Modulation of Gene Expression by Dietary Zinc

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"The text is divided into 22 chapters written by experts in nutrition, physiology and pharmacology from several countries. The main issues reviewed are oxidants, antioxidants and gene expression, and relationships between gene expression and nutrient related diseases."
-Pediatric Endocrinology Reviews, Vol. 3, No. 2, Dec. 2005