504 Pages 83 B/W Illustrations
    by CRC Press

    Nutritional genomics, also referred to as nutrigenomics, is considered one of the next frontiers in the post-genomic era. Its fundamental premise is that while alterations in gene expression or epigenetic phenomena can subvert a healthy phenotype into manifesting chronic disease, through the introduction of certain nutrients, this process can be reversed or modified. Employing state-of-the-art genomic and proteomic investigations that monitor the expression of thousands of genes in response to diet, nutrigenomics investigates the occurrence of relationship between dietary nutrients and gene expression.

    Nutrigenomics was compiled to update the reader on recent advances in this emerging field. Over forty experts in nutrition, physiology, pathology, pharmacology, and the microbial sciences from all across the world present cutting-edge developments and emerging methods presently used in nutrigenomics. They include the latest studies and research on the role of oxidants, antioxidants, phytochemicals, and micronutrients in the modulation of gene expression affecting aging, immune function, carcinogenesis, and vascular health. As most human diseases are largely avoidable by lifestyle changes, this places nutrigenomics at the forefront of preventive medicine.

    Application of Nutrigenomics Tools to Analyze the Role of Oxidants and Antioxidants in Gene Expression, Gerald Rimbach and Sonia De Pascual-Teresa
    Oxidative Stress and Human Genetic Variation, R. D. Gill-Garrison, J. L. Slater, and K. Grimaldi
    Analysis of Microarray Data, Ken Mills
    Oxidative Stress, Gene Expression, and Lifespan, Yoko Honda and Shuji Honda
    Anti-Oxidant Modulation in Immune Function, Robert Francis Grimble
    Concentration-Dependent Gene and Protein Expressions of Neuroprotective and Neurotoxic Activities of Antioxidants, Including Nutrients, Orly Weinreb, Silvia Mandel, and Moussa B. H. Youdim
    Effects of Antioxidants on Gene Expression in Endothelial Cells, B. A. Nier, B. A. Ewins, S. G. Cremers, and Peter D. Weinberg
    Fatty Acids, Gene Expression, and Coronary Heart Disease (CHD), Anne M. Minihane
    Cell Regulatory Activity of Tocopherols and Tocotrienols, Cristina Rota, Anne M. Minihane, Peter D. Weinberg, Stefan Weber, John K. Lodge, Lester Packer, and Gerald Rimbach
    Molecular Analysis of the Vitamin A Biosynthetic Pathway, Johannes von Lintig
    Molecular Mechanisms Underlaying the Health Promoting Activity of Lycopene, Estibaliz Olano-Martin
    Cellular Redox Activity and Molecular Functions of Ascorbic Acid, John K. Lodge
    Cell Signaling Properties of a-Lipoic Acid: Implications in Type 2 Diabetes, Hadi Moini, Lester Packer, Kyung-Joo Cho, and An-Sik Chung
    Dietary Isoflavones and Coronary Artery Disease-Proposed Molecular Mechanisms of Action, Aedin Cassidy and Sonia De Pascual-Teresa
    Anti-Carcinogenic Properties of Soy Isoflavones, Max O. Bingham and Glenn R. Gibson
    Effect of Ginkgo biloba Extract EGb 761on Differential Gene Expression in the Brain, Rainer Cermak and Siegfried Wolffram
    Interactions of Flavonoids and Their Metabolites with Cell Signaling Cascades, Jeremy P. E. Spencer
    Antioxidant and Gene Regulatory Properties of Procyanidins, R. Canali, R. Ambra, O. Gulati, and F. Virgili
    Cell Signaling Properties of Inositol Hexaphosphate (IP6), Abulkalam M. Shamsuddin
    Modulation of Gene Expression by Dietary Iron, Paul Sharp
    Dietary Selenium and Gene Expression, Alexandra Fischer and Josef Pallauf
    Modulation of Gene Expression by Dietary Zinc, Raymond K. Blanchard and Robert J. Cousins

    Short TOC


    Gerald Rimbach, Jörgen Fuchs

    "The text is divided into 22 chapters written by experts in nutrition, physiology and pharmacology from several countries. The main issues reviewed are oxidants, antioxidants and gene expression, and relationships between gene expression and nutrient related diseases."
    -Pediatric Endocrinology Reviews, Vol. 3, No. 2, Dec. 2005