Nutrigenomics: 1st Edition (Hardback) book cover


1st Edition

Edited by Gerald Rimbach, Jürgen Fuchs

CRC Press

504 pages | 83 B/W Illus.

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Hardback: 9780824726638
pub: 2005-05-23
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Nutritional genomics, also referred to as nutrigenomics, is considered one of the next frontiers in the post-genomic era. Its fundamental premise is that while alterations in gene expression or epigenetic phenomena can subvert a healthy phenotype into manifesting chronic disease, through the introduction of certain nutrients, this process can be reversed or modified. Employing state-of-the-art genomic and proteomic investigations that monitor the expression of thousands of genes in response to diet, nutrigenomics investigates the occurrence of relationship between dietary nutrients and gene expression.

Nutrigenomics was compiled to update the reader on recent advances in this emerging field. Over forty experts in nutrition, physiology, pathology, pharmacology, and the microbial sciences from all across the world present cutting-edge developments and emerging methods presently used in nutrigenomics. They include the latest studies and research on the role of oxidants, antioxidants, phytochemicals, and micronutrients in the modulation of gene expression affecting aging, immune function, carcinogenesis, and vascular health. As most human diseases are largely avoidable by lifestyle changes, this places nutrigenomics at the forefront of preventive medicine.


"The text is divided into 22 chapters written by experts in nutrition, physiology and pharmacology from several countries. The main issues reviewed are oxidants, antioxidants and gene expression, and relationships between gene expression and nutrient related diseases."

-Pediatric Endocrinology Reviews, Vol. 3, No. 2, Dec. 2005

Table of Contents

Application of Nutrigenomics Tools to Analyze the Role of Oxidants and Antioxidants in Gene Expression, Gerald Rimbach and Sonia De Pascual-Teresa

Oxidative Stress and Human Genetic Variation, R. D. Gill-Garrison, J. L. Slater, and K. Grimaldi

Analysis of Microarray Data, Ken Mills

Oxidative Stress, Gene Expression, and Lifespan, Yoko Honda and Shuji Honda

Anti-Oxidant Modulation in Immune Function, Robert Francis Grimble

Concentration-Dependent Gene and Protein Expressions of Neuroprotective and Neurotoxic Activities of Antioxidants, Including Nutrients, Orly Weinreb, Silvia Mandel, and Moussa B. H. Youdim

Effects of Antioxidants on Gene Expression in Endothelial Cells, B. A. Nier, B. A. Ewins, S. G. Cremers, and Peter D. Weinberg

Fatty Acids, Gene Expression, and Coronary Heart Disease (CHD), Anne M. Minihane

Cell Regulatory Activity of Tocopherols and Tocotrienols, Cristina Rota, Anne M. Minihane, Peter D. Weinberg, Stefan Weber, John K. Lodge, Lester Packer, and Gerald Rimbach

Molecular Analysis of the Vitamin A Biosynthetic Pathway, Johannes von Lintig

Molecular Mechanisms Underlaying the Health Promoting Activity of Lycopene, Estibaliz Olano-Martin

Cellular Redox Activity and Molecular Functions of Ascorbic Acid, John K. Lodge

Cell Signaling Properties of a-Lipoic Acid: Implications in Type 2 Diabetes, Hadi Moini, Lester Packer, Kyung-Joo Cho, and An-Sik Chung

Dietary Isoflavones and Coronary Artery Disease-Proposed Molecular Mechanisms of Action, Aedin Cassidy and Sonia De Pascual-Teresa

Anti-Carcinogenic Properties of Soy Isoflavones, Max O. Bingham and Glenn R. Gibson

Effect of Ginkgo biloba Extract EGb 761on Differential Gene Expression in the Brain, Rainer Cermak and Siegfried Wolffram

Interactions of Flavonoids and Their Metabolites with Cell Signaling Cascades, Jeremy P. E. Spencer

Antioxidant and Gene Regulatory Properties of Procyanidins, R. Canali, R. Ambra, O. Gulati, and F. Virgili

Cell Signaling Properties of Inositol Hexaphosphate (IP6), Abulkalam M. Shamsuddin

Modulation of Gene Expression by Dietary Iron, Paul Sharp

Dietary Selenium and Gene Expression, Alexandra Fischer and Josef Pallauf

Modulation of Gene Expression by Dietary Zinc, Raymond K. Blanchard and Robert J. Cousins


Short TOC

About the Series

Oxidative Stress and Disease

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Nutrition
SCIENCE / Life Sciences / Genetics & Genomics
SCIENCE / Life Sciences / Biology / Molecular Biology