The Functional Fold : Amyloid Structures in Nature book cover
1st Edition

The Functional Fold
Amyloid Structures in Nature

ISBN 9789814267403
Published August 23, 2012 by Jenny Stanford Publishing
198 Pages 28 Color & 26 B/W Illustrations

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Book Description

Bringing together a wide variety of examples of functional amyloid in a single volume, this book explores the importance of amyloid fibrils in fungi, bacteria, algae, invertebrate, and vertebrate animals for providing environmental protection, structural integrity, and regulating biochemical processes. It highlights many of the extraordinary examples of functional amyloid found to date. It, therefore, provides an exciting perspective for the study of amyloid deposits as important and useful protein structures widespread in nature.

Table of Contents

The World of Functional Amyloid
Protein Misfolding and Aggregation
Structural Properties of Amyloid
Amyloid Formation Mechanisms
Amyloid as a Pathological Entity
Amyloid Is a Functional Protein Quaternary Structure
Challenges and Future Directions
Hagfish Slime Threads
Are Hagfish Slime Threads "Disposable Amyloid"?
Slime Threads Are Bundles of Intermediate Filaments
Mechanical Properties
Structural Considerations
Implications for Other Materials Containing Intermediate Filaments
Conclusions and Outlook
Fungal Fibrils: Application of the Amyloid Polymer Structure by Fungi
Early Observations of Rodlets
The Two Classes of Hydrophobins
Hydrophobins and Amyloid
Structural Change During Rodlet Formation
Specialization and Functional Significance of These Functional Amyloids
Silkmoth Chorion: A Natural Protective Amyloid
Silkmoth Chorion Protein Peptide-Analogues
Model Structure of Silkmoth Chorion Amyloidogenic Peptides
Sikmoth Chorion: A Natural Protective Amyloid
Spider Silk
Overview of Silk Structure, Mechanics, and Assembly
Yeast Prions: Their Assembly into Protein Fibrils and the Role of Assembly Modulators
Prions in Yeast
The [PSI+], [PIN], [URE3], and [Het-s] Phenotypes
In vitro Assembly of Sup35p, Rnq1p, Ure2p, and HET-s into Protein Fibrils
Structural Basis of Yeast Prion Propagation
Structural Models at an Atomic Resolution for Fibrillar Prion Proteins
Molecular Chaperones and the Propagation of Yeast Prions
Nature of the Infectious Form of Yeast Prions
Conclusions and Outlook
Curli Extracellular Matrix
Bacterial Biofilms and the Curli Extracellular Matrix
The Curli Gene Cluster
From Regulation to Secretion
Curli Biogenesis: Mechanism, Kinetics, and Fibril Structure
Functional Role of Curli
Amyloid-Based Natural Adhesives and Cements
Introduction to Natural Adhesives
Amyloid in Natural Adhesives
AFM as a Tool for Exploring Natural Adhesives
Biomimetic Development of Amyloid- Inspired Adhesives
Mammalian Functional Amyloid
Amyloid as a Structural and Regulatory Component of Haemostasis
Amyloid Coordinates Melanin Biosynthesis in Mammals
Unfolding the Future
The Field to Date
The Challenge of Identification
The Latest Discoveries
Relevance to the Field of Pathogenic Amyloid
Applications of Functional Amyloid

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