The Functional Fold: Amyloid Structures in Nature, 1st Edition (Hardback) book cover

The Functional Fold

Amyloid Structures in Nature, 1st Edition

Edited by Suzi Jarvis, Anika Mostaert

Pan Stanford

184 pages | 28 Color Illus. | 26 B/W Illus.

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pub: 2012-08-23
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Description

Bringing together a wide variety of examples of functional amyloid in a single volume, this book explores the importance of amyloid fibrils in fungi, bacteria, algae, invertebrate, and vertebrate animals for providing environmental protection, structural integrity, and regulating biochemical processes. It highlights many of the extraordinary examples of functional amyloid found to date. It provides an exciting perspective for the study of amyloid deposits as important and useful protein structures widespread in nature.

Table of Contents

The World of Functional Amyloid

Protein Misfolding and Aggregation

Structural Properties of Amyloid

Amyloid Formation Mechanisms

Amyloid as a Pathological Entity

Amyloid Is a Functional Protein Quaternary Structure

Challenges and Future Directions

Hagfish Slime Threads

Introduction

Are Hagfish Slime Threads "Disposable Amyloid"?

Slime Threads Are Bundles of Intermediate Filaments

Mechanical Properties

Structural Considerations

Implications for Other Materials Containing Intermediate Filaments

Conclusions and Outlook

Fungal Fibrils: Application of the Amyloid Polymer Structure by Fungi

Introduction

Early Observations of Rodlets

The Two Classes of Hydrophobins

Hydrophobins and Amyloid

Structural Change During Rodlet Formation

Specialization and Functional Significance of These Functional Amyloids

Conclusions

Silkmoth Chorion: A Natural Protective Amyloid

Introduction

Silkmoth Chorion Protein Peptide-Analogues

Model Structure of Silkmoth Chorion Amyloidogenic Peptides

Sikmoth Chorion: A Natural Protective Amyloid

Spider Silk

Introduction

Overview of Silk Structure, Mechanics, and Assembly

Conclusion

Yeast Prions: Their Assembly into Protein Fibrils and the Role of Assembly Modulators

Introduction

Prions in Yeast

The [PSI+], [PIN], [URE3], and [Het-s] Phenotypes

In vitro Assembly of Sup35p, Rnq1p, Ure2p, and HET-s into Protein Fibrils

Structural Basis of Yeast Prion Propagation

Structural Models at an Atomic Resolution for Fibrillar Prion Proteins

Molecular Chaperones and the Propagation of Yeast Prions

Nature of the Infectious Form of Yeast Prions

Conclusions and Outlook

Curli Extracellular Matrix

Bacterial Biofilms and the Curli Extracellular Matrix

The Curli Gene Cluster

From Regulation to Secretion

Curli Biogenesis: Mechanism, Kinetics, and Fibril Structure

Functional Role of Curli

Summary

Amyloid-Based Natural Adhesives and Cements

Introduction to Natural Adhesives

Amyloid in Natural Adhesives

AFM as a Tool for Exploring Natural Adhesives

Biomimetic Development of Amyloid- Inspired Adhesives

Conclusions

Mammalian Functional Amyloid

Amyloid as a Structural and Regulatory Component of Haemostasis

Amyloid Coordinates Melanin Biosynthesis in Mammals

Conclusion

Unfolding the Future

The Field to Date

The Challenge of Identification

The Latest Discoveries

Relevance to the Field of Pathogenic Amyloid

Applications of Functional Amyloid

Conclusions

Subject Categories

BISAC Subject Codes/Headings:
SCI049000
SCIENCE / Life Sciences / Biology / Molecular Biology
SCI055000
SCIENCE / Physics