1st Edition

Flavonoids and Anti-Aging The Role of Transcription Factor Nuclear Erythroid 2-Related Factor2

    292 Pages 39 B/W Illustrations
    by CRC Press

    The nuclear factor erythroid 2-related factor 2 (Nrf2) was described as a master regulator of the cellular antioxidant response. Moreover, many critical biological functions linked to cell viability, metabolism, autophagy, inflammation, immunity, and differentiation have been attributed to Nrf2, which regulates over 600 genes. It is well known that oxidative stress, which Nrf2 can ameliorate, plays a key role in many pathologic processes such as aging, obesity, diabetes, cancer, and neurodegenerative diseases.

    Flavonoids, on the other hand, through their ability to activate and upregulate Nrf2, can have anti-oxidative, anti-inflammatory, anti-mutagenic, and anti-carcinogenic properties. Flavonoids are an essential ingredient in nutraceuticals, functional foods, and pharmaceuticals. The present book Flavonoids and Anti-Aging: The Role of Transcription Factor Nuclear Erythroid 2-Related Factor2 focuses on the interaction between Nrf2 and flavonoids and their applications in various conditions such as aging, osteoporosis, cardiovascular diseases, and neurodegenerative disease and many other areas.

    Key Features:

    • Focuses on the mechanisms and use of flavonoids in activating Nrf2 as an anti-aging and "WELLNESS" molecule
    • Provides a specific approach to flavonoid activation of Nrf2 and its implications in aging and various disease conditions and its applications as nutraceuticals
    • Presents flavonoid-based functional foods
    • Discusses the flavonoid nutraceuticals market and future trends

    Written by experts in the field, this book provides a unique approach to understanding the flavonoid activation of the transcription factor Nrf2, which is responsible for many different disease conditions due to increased reactive oxidative species in the body caused by some physiological triggers.

    1. Flavonoids: Sources, Chemical Classification and
    2. Pharmacological Activities,

      Madhavi Gangapuram and Kinfe K. Redda

    3. Flavonoids classification and their applications as nutraceuticals
    4. Augustine Nkembo


    5. Role of NRF2 in Flavonoids anticancer activity
    6. Patricia Mendonca

    7. The Role of Nrf2 Activation and Autophagy in Aging, and Neurodegenerative Diseases,
    8. Elizabeth Mazzio and Karam Soliman

    9. Role of Flavonoids Activation of Nrf2 in Neurodegenerative Disease and
    10. Brain Aging

      Equar Taka, Getinet M. Adinew, Karam F. A. Soliman

    11. Aging, hearing loss and Nrf2
    12. Charles A Lewis

    13. NRF2 and ocular aging: Flavonoid and Nutraceuticals Use
    14. Aaron L Hillard and Tanya Russel

    15. Role of NRF2 in Obesity and flavonoid action
    16. Seth Kwabena Amponsah, Emmanuel Boadi Amoafo and Emmanuel Kwaku Ofori

    17. Flavonoids Activation of Nrf2 and Osteoporosis
    18. Samia Messeha

    19. NRF2 Cardiovascular diseases and aging and Flavonoid nutraceuticals
    20. Seth Kwabena Amponsah and Emmanuel Boadi Amoafo

    21. NRF2 The aging liver
    22. Aparoop Das, Kalyani Pathak, Manash Pratim Pathak, Urvashee Gogoi, Riya Saikia

    23. Flavonoids based Functional Foods

    Archita Jha and Yashwant V Pathak


    Karam F.A. Soliman is the Associate Dean for Research and Graduate Studies and Distinguished Professor of Pharmaceutical Sciences at the College of Pharmacy and Pharmaceutical Sciences Institute of Public Health of Florida A&M University (FAMU). Dr. Soliman received his M.S. and Ph.D. degrees in Physiology from the University of Georgia in 1971 and 1972. He started his professional career in 1972 as an assistant professor of Physiology at the School of Veterinary Medicine of Tuskegee Institute. He moved to FAMU in 1975, where he was involved with the Research Center in Minority Institution (RCMI) program for 36 years since its inception in 1985. Also, his record includes the training of 30 PhDs in Pharmacology/Toxicology. He has published extensively in national and international refereed journals (203) publications. His record includes one book, five book chapters, and 4 U.S. patents. His research has been supported by NIH, NASA, Office of Naval Research, and Department of Energy grants. During his tenure at FAMU, he was awarded federal grants totaling over $ 96 million. Dr. Soliman's research interests in cancer have been focused on cancer cell pH as a crucial factor in the biological functions of cancer cell proliferation, invasion, metastasis, drug resistance, and apoptosis. Also, the involvement of NRF2 in aging, COVID 19, neurodegeneration, and cancer. Dr. Soliman is a member of the Society for Neuroscience, American Society of Pharmacology and Experimental Therapeutics, American Physiological Society, American Society for Investigative Pathology, Endocrine Society, Society of Experimental Biology and Medicine, and the American Association of Cancer Society.


    Dr. Yashwant V. Pathak completed Ph.D. in Pharmaceutical Technology from Nagpur University, India and EMBA & MS in Conflict Management from Sullivan University. He is Professor and Associate Dean for Faculty Affairs at College of Pharmacy, University of South Florida. Tampa, Florida. With extensive experience in academia as well as industry, he has more than 300 research publications, including research papers, chapters and reviews, and 3 US patent approved. Dr Pathak has over  62 edited books published, in Nanotechnology,  Nutraceuticals and drug delivery systems. He has several edited books in cultural studies and conflict management . He has received several National and International awards including two times Fulbright awards. Dr Pathak is selected as fellow of American Association for the Advancement of Sciences (FAAAS) in 2021. Dr Yashwant Pathak is also an Adjunct Professor at Faculty of Pharmacy, Airlangga University, Surabaya, Indonesia.