1st Edition

Anxiety, Gut Microbiome, and Nutraceuticals Recent Trends and Clinical Evidence

Edited By Yashwant V. Pathak, Sarvadaman Pathak, Con Stough Copyright 2024
    440 Pages 32 Color & 6 B/W Illustrations
    by CRC Press

    440 Pages 32 Color & 6 B/W Illustrations
    by CRC Press

    Healthy gut function is associated with normal central nervous system (CNS) function. Hormones, neurotransmitters, and immunological factors released from the gut are known to send signals to the brain either directly or via autonomic neurons. Recently, studies have emerged focusing on variations in the microbiome and the effect on various CNS disorders, including, but not limited to anxiety, depressive disorders, schizophrenia, and autism. Anxiety, Gut Microbiome, and Nutraceuticals: Recent Trends and Clinical Evidence is focused on understanding the role of gut microbiomes on anxiety and how it can be treated using various nutraceuticals. It covers recent trends and clinical evidence in application of nutraceuticals in treating anxiety and related disorders.

    Key Features

    • Explains various factors related to anxiety and anxiety-related disorders including pathophysiological and pharmacological factors
    • Discusses the pharmacology behind anxiety and related disorders
    • Explores the role of gut microbiota and its relationship with anxiety and related disorders
    • Describes different nutraceuticals and classes of nutraceuticals which can be useful to treat anxiety and related disorders

    In recent years, there has been an increased interest in nutraceuticals and their applications in treating many diseases and disorders. The market has grown tremendously, and this book focuses on the many clinical studies reporting on the usefulness of nutraceuticals in treating such health conditions.

    1. Nutraceuticals and its applications –recent trends and challenges

    Shilpi Saxena, Roshni Singh, Debopriya Dutta, Namrata Gautam,

    Sonal Setya, and Sushama Talegaonkar

    2 Anxiety disorders: background, anatomy and pathophysiology

    Ashely Oake and Yashwant Pathak

    3 Diagnosis and management of anxiety disorders

    Erik Feldtmann, Pier Pointdujour, Carlos Bellido, and Charles Preuss

    4. Anxiety disorders: Symptoms and causes

    Rena Jiang, Katherine Tsa, Steven Herd-Bond, Carlos Bellido,

    and Charles Preuss

    5 Pharmacology of human anxiety, Carrie Wang, Jonathan Charles,

    Grant Morrison, Thomas Wotherspoon, and Charles Preuss

    6 Gut Microbiota and Mental Health: The Gut Brain Axis

    Ashley Oake, Nicole Nesto, and Yashwant V Pathak

    7 Inflammation and the gut microbiome in depression and anxiety

    Komal Parmar, Sai Patel and Jayvadan Patel

    8 Stress, depression, diet, and the gut microbiota: human–bacteria

    Interactions at the core of psychoneuroimmunology and nutrition

    Malcolm Padgett, Jad Mouslle, and Dr. Yashwant Pathak

    9 Effects of Psychological, Environmental, and Physical Stressors on the

    Gut Microbiota, Abdullah Abdelkawi, Diban Sabbagh, Muhammed Hobi

    and Yashwant Pathak

    10 Translating evidence to real-world reproducibility and specific evidence for

    Nutraceuticals, Emily Evangelista, Patrick Chan, Thomas Shen, Rahul Mhaskar

    11. Nutraceuticals as modulators of gut microbiota: Role in therapy!

    Rupali Joshi Panse

    12 Stress disorder and gut microbiota, Triveni Shelke Sushama

    Talegaonkar and Monalisa Mishra

    13. Polyphenolic Nutraceuticals to Combat Oxidative Stress Through

    Microbiota Modulation, Aaishwarya B Deshmukh, and Jayvadan K. Patel

    14 The Role of Functional Foods and Nutraceuticals in Gastrointestinal Health

    Dan Du Bourdieu, Jamil Talukder, Ajay Srivastava, Rajiv Lall, Ramesh C. Gupta

    15 Traditional therapy of prebiotics and probiotics as treatment for anxiety and stress

    Jesna John and Yashwant Pathak

    16 Oral β-Lactamase Therapies Designed for the Prevention of Antibiotic-Induced Disruption of the Gut Microbiome, Sabrina Strelow, Sarvadaman Pathak

    and Yashwant V Pathak

    17 Recent trends in the role of the human gut microbiome in neurological function

    and brain disorders, Addie Pitts, Kevin Sneed and Yashwant Pathak

    18 Synbiotic: Traditional Approach, Present Status and Future Outlook

    Abdullah Abdelkawi, Jean Pierre Perez Martinez, Sarvadaman Pathak

    and Yashwant Pathak

    19 Interplay between nutraceuticals and gut microbiota some clinical evidences

    Aaishwarya B Deshmukh and Jayvadan K. Patel

    20 Manipulation of Gut Microbiome to Improve Mental Health

    Sathya Amarasena and Shyamchand Mayengbam

    21 Functional Constituents of Yacon (Smallanthus sonchifolius) for

    gut rejuvenation, Abdullah Abdelkawi, Philopateer Messeha

    and Yashwant Pathak


    Sarvadaman Pathak, MD, went to University of Houston for undergraduate studies, with a concentration in Biochemistry and Pre-Medicine. Following that he pursued a Doctor of Medicine degree from Avalon University School of Medicine Summa Cum Laude. He was educated partially in Belize, Mexico with all clinical experience in Chicago, IL. After graduating from medical school, he focused on research and worked at the University of South Florida. In 2013 he completed a one-year clinical fellowship in Traditional Chinese Medicine, including Chinese herbalism, with a focus on eastern western integrative medicine at the Dalian Medical University in Dalian, Liaoning province in Mainland China. Currently he works for the Veterans Affairs and University o fSouth Florida, Internal Medicine, and focuses on cancer research and pediatrics research.

    Yashwant V. Pathak, PhD, is currently the associate dean for faculty affairs at College of Pharmacy, University of South Florida, Tampa, Florida. Pathak earned his MS and PhD degrees in pharmaceutical technology from Nagpur University, Nagpur, India, and EMBA and MS degrees in conflict management from Sullivan University, Louisville, Kentucky. With extensive experience in academia and industry, Pathak has over 150 publications, research papers, abstracts, book chapters, and reviews to his credit. He has presented over 180 presentations, posters, and lectures worldwide in the field of pharmaceuticals, drug delivery systems, and other related topics. He has received several national and international awards including Fulbright Senior Scholar fellowship for Indonesia, Endeavour executive fellowship from Australian Government, CNPQ research award from Brazil Government and also was recognized by USF as outstanding faculty award and global engagement achievement award.

    Con Stough, PhD, is Professor of Cognitive Neuroscience and Psychology and Director, Centre for Human Psychopharmacology. He earned his Bachelor of Science (Hons), University of Adelaide, Australia; PhD, University of Adelaide, Australia. Professor Con Stough’s research interest lies in understanding human intelligence and cognition. He examines this central question from both psychological and biological perspectives, particularly using pharmacological methods.

    A significant part of this research aims towards a better understanding of the cognitive and psychological effects of pharmacologically active substances ranging from illicit drugs to herbal and nutrient medicines. This includes validating new and existing nutritional products that may have a pharmacological profile useful in cognitive enhancement – for example, the bacopa extract CDRI08. More broadly, Professor Stough’s research contributes to the development of nutritional products that can improve brain and cognitive function in Australia and overseas. In other research, Professor Stough has been working closely with partner schools from Australia and New Zealand to develop measures of emotional intelligence that can be used as development programs for children of all ages. This school-based research and development coalition is known as Aristotle Emotional Intelligence.